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M94A0297.TXT
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1994-10-08
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Document 0297
DOCN M94A0297
TI Molecular characterization of murine and human OX40/OX40 ligand systems:
identification of a human OX40 ligand as the HTLV-1-regulated protein
gp34.
DT 9412
AU Baum PR; Gayle RB 3rd; Ramsdell F; Srinivasan S; Sorensen RA; Watson ML;
Seldin MF; Baker E; Sutherland GR; Clifford KN; et al; Department of
Gene Expression, Immunex R&D Corporation, Seattle,; WA 98101.
SO EMBO J. 1994 Sep 1;13(17):3992-4001. Unique Identifier : AIDSLINE
GENBANK/U12763
AB A ligand was cloned for murine OX40, a member of the TNF receptor
family, using a T cell lymphoma cDNA library. The ligand (muOX40L) is a
type II membrane protein with significant identity to human gp34 (gp34),
a protein whose expression on HTLV-1-infected human leukemic T cells is
regulated by the tax gene. The predicted structures of muOX40L and gp34
are similar to, but more compact than, those of other ligands of the TNF
family. Mapping of the muOX40L gene revealed tight linkage to gld, the
FasL gene, on chromosome 1. gp34 maps to a homologous region in the
human genome, 1q25. cDNAs for human OX40 receptor were cloned by
cross-hybridization with muOX40, and gp34 was found to bind the
expressed human receptor. Lymphoid expression of muOX40L was detected on
activated T cells, with higher levels found on CD4+ rather than CD8+
cells. The cell-bound recombinant ligands are biologically active,
co-stimulating T cell proliferation and cytokine production. Strong
induction of IL-4 secretion by muOX40L suggests that this ligand may
play a role in regulating immune responses. In addition, the HTLV-1
regulation of gp34 suggests a possible connection between virally
induced pathogenesis and the OX40 system.
DE Amino Acid Sequence Animal Antigens, CD27/GENETICS/*METABOLISM Base
Sequence Chromosome Mapping Chromosomes, Human, Pair 1 Cloning,
Molecular Comparative Study Cytokines/BIOSYNTHESIS Female Gene
Expression Regulation Human HTLV-I/METABOLISM Ligands Mice Mice,
Inbred C57BL Models, Molecular Molecular Sequence Data Receptors,
Tumor Necrosis Factor/*GENETICS/*METABOLISM Recombinant Fusion
Proteins/METABOLISM Sequence Homology, Amino Acid Support, Non-U.S.
Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/METABOLISM Tumor
Necrosis Factor/*GENETICS/*METABOLISM JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).